Intestinal flora vary greatly among individuals.
Recently, Chinese actress and director Jia Ling has become “popular”. She is popular partly because of the movie “Hot and Spicy” she directed, but also because of her weight loss. She lost weight in less than a year. 100 pounds. When you paid attention to her weight loss, you saw the apparent high-intensity professional fitness exercises and scientific and reasonable nutritional weight loss meals. And did you pay attention to the changes in the microscopic intestinal flora in Jia Ling’s body before and after she lost weight?
A growing body of research shows that different individuals have very different responses to the same food, reflected in post-meal blood sugar, disease intervention and treatment effects. An important reason for the differences is the different intestinal flora between individuals.
Recently, a research team from the Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, revealed the important role of intestinal flora in guiding precision nutritional intervention to improve metabolic syndrome. This research result was published online in the international academic journal “Molecular Nutrition and Food Research”.
【The prevalence of metabolic syndrome among Chinese adults has reached 33.9%】
Metabolic syndrome refers to a pathological state in which metabolic disorders occur in the human body. Abdominal obesity is the core feature. Abnormal glucose and lipid metabolism, hypertension, etc. are also important pathological manifestations. Metabolic syndrome is a high-risk factor for the development of type 2 diabetes, non-alcoholic fatty liver disease, atherosclerosis and other diseases. Metabolic syndrome and related diseases caused by unreasonable eating habits and improper lifestyle have become a global problem. Major public health issues. The latest data shows that the prevalence of metabolic syndrome among Chinese adults has reached 33.9%, and it is estimated that approximately 454 million adults nationwide suffer from metabolic syndrome.
In a preliminary study, the research team conducted a 12-week dietary intervention study for metabolic syndrome and high-risk groups. Using peanuts to replace energy-rich refined grain products can significantly improve metabolic syndrome without gaining weight. Symptom reversal rate.
The research team collected and analyzed intestinal flora for this clinical study, and found that the changes in clinical test indicators and body measurement indicators after peanut intervention showed a high degree of individual variability. “There are 10 trillion bacteria living in the human intestine. By analyzing the intestinal flora samples before and after peanut intervention, we found that the individual intestinal flora vary greatly.”
【Different intestinal flora affect the level of reversal of metabolic syndrome】
In view of the differences in the response of the population to peanut intervention, the researchers divided the peanut intervention group into responders and non-responders based on the improvement of each metabolism-related indicator and the reversal of the risk of metabolic syndrome. The researchers applied machine learning algorithms and used the characteristics of bacterial sequencing data of pre-intervention samples to establish a response prediction model for each indicator and the overall risk reversal of metabolic syndrome.
“Among the 9 clinical indicators we tested, the prediction models for 6 indicators achieved certain prediction results, especially in predicting the intervention effects of diastolic blood pressure and weight with high accuracy; in addition, metabolic syndrome The overall risk reversal can also be better predicted through the model.” Therefore, different intestinal flora affect the overall risk reversal level of metabolic syndrome.
In recent years, much research evidence has shown that intestinal flora is a key feature of precision nutrition. The so-called precision nutrition means that when people choose food or perform nutritional intervention, they regard themselves as a super symbiosis of humans and microorganisms, and optimize health or prevent, manage, and treat diseases through personalized nutritional support.
This study demonstrates the key position of intestinal flora in precision nutrition intervention to improve metabolism and treat disease strategies, and provides a basis for subsequent research on using intestinal flora as a target for functional foods or drugs, or for the development of larger-scale precision nutrition. Intervention and clinical application provide new ideas and theoretical basis.
In the future life, may we eat healthy, exercise scientifically, and pay attention to our intestinal health. We must truly radiate the charm of health from the inside out.
The future is promising, and I hope we can go further and further on the road ahead