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Pet Nutrition Excipients: Why Low Water Activity Is the Fastest-Growing Spec Pet nutrition and supplement brands are increasingly formulating with the same rigor human nutraceutical brands apply. Probiotic strains, active enzymes, and moisture-sensitive actives are all common in premium pet supplement lines today, and pet nutrition excipients are catching up to meet the same water […]

Low Water Activity Tablets: Why Effervescent and ODT Formulas Need Tighter Control Effervescent tablets and orally disintegrating tablets (ODTs) are two of the least forgiving dosage forms when it comes to excipient moisture. Getting low water activity tablets right in these formats isn’t optional polish — it’s often the difference between a stable shelf life

Moisture Sensitive API Excipients: A Practical Guide to Protecting Unstable Actives Some active ingredients degrade primarily through hydrolysis — ester- and acetal-containing molecules being the clearest examples. For these compounds, moisture sensitive API excipients aren’t a passive filler choice; they either protect the active from ambient moisture or actively contribute to its degradation pathway. This

Probiotic Carrier Water Activity: 5 Rules for Choosing the Right Filler Probiotic formulators rarely debate whether water activity matters. They debate exactly where to draw the line. For many strains, carriers and fillers are specified at a low Aw threshold — often below roughly 0.2 to 0.3 — because residual free water is one of

Critical Relative Humidity Excipients: The One Number That Predicts Moisture Failure Every hygroscopic powder has a tipping point. Below a certain ambient relative humidity, it barely absorbs water. Cross that threshold, and absorption accelerates sharply. Understanding critical relative humidity excipients — and where that threshold sits for the specific materials in your formulation — is

Water Activity Excipients: 7 Facts Formulators Get Wrong About Moisture Most Certificates of Analysis for water activity excipients still report only one moisture number: LOD, loss on drying. It’s easy to measure and easy to put on a spec sheet. On its own, though, it’s a surprisingly poor predictor of whether an excipient will destabilize